Gut Balance-Disease Association Database

The human Gut Balance-Disease Association Database (GBDAD) provides 2544 non-redundant balance-disease associations from metagenome samples and 7014 from amplicon samples. For each pair of balance-disease association, the balance degree (the number of diseases related to the balance), the MeSH (Medical Subject Headings) id of the disease, the LR coefficient of the balance-disease association, the scientific name of the species in the numerator and denominator, and the evidence score of the species-disease association in MicroPhenoDB were provided. The database supports the interactive exploration of these balance-disease and species-disease associations by searching or filtering.

Disease-Balance association in GutBalance


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A. Network of all the disease-balance associations for all the 37 disease phenotypes from metagenome samples. The red nodes represent different diseases. The size of the disease node indicates the degree of the node, namely, the number of balances related to this disease. The disease nodes are labeled by the MeSH ids. The edges represent the associations with the absolute value of LR coefficient larger than 0.5. The width and the transparency of the edge indicate the absolute value of LR coefficient of the association. The color of the edge indicates the positive (red) or negative (blue) association. B. Heatmap of of top 20 disease-balance associations for all the 37 disease phenotypes from metagenome samples. The balances with degree larger than 2 (>=3) are specifically marked as red circles, which indicates these balances are positively or negatively correlated with multiple diseases. C. The heatmap of the species partitions of the balances with degree larger than 2 and the evidence score of the species-disease association in MicroPhenoDB.


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缩略图
B
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C
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Click the image to see the HD version

A. Network of all the disease-balance associations for all the 54 disease phenotypes from amplicon samples. The red nodes represent different diseases. The size of the disease node indicates the degree of the node, namely, the number of balances related to this disease. The disease nodes are labeled by the MeSH ids. The edges represent the associations with the absolute value of LR coefficient larger than 0.5. The width and the transparency of the edge indicate the absolute value of LR coefficient of the association. The color of the edge indicates the positive (red) or negative (blue) association. B. Heatmap of of top 20 disease-balance associations for all the 54 disease phenotypes from amplicon samples. The balances with degree larger than 5 (>=6) are specifically marked as red circles, which indicates these balances are positively or negatively correlated with multiple diseases. C. The heatmap of the species partitions of the balances with degree larger than 2 and the evidence score of the species-disease association in MicroPhenoDB.



Human Gut Balance-Disease Association Database

Please be patient as the interactive database loads a bit slow.

Heading abbreviationsfor each column of the table:
LRcoef: coefficients of the predictable balances for the model.
NumeratorS: species in the numerator of the balance.
Denominator1S and Denominator2S: species in the denominator of the balance.
NumeratorE, Denominator1E, Denominator2E: species-disease association evidence for the species in the NumeratorS, Denominator1S, and Denominator2S columns.
Notes: The species-disease association evidence is represented by the disease name and the association score linked by an underline (e. g. Cirrhosis of liver_-1.31). The associations with scores greater than 0.3 or lesser than -0.3 are more confident. By linking the balance-disease associations in GBDAD and the evidenced species-disease associations from the MicroPhenoDB database, the new species-disease associations can be directly inferred as shown on the “Tutorial” page.

Evidences and taxon-disease association inferences for matched disease

It should be noted that a balance that increases or decreases in a specific disease only reflects a bacteria ratio positively or negatively correlated with the disease, which does not describe the detailed relationship between the balance-related species and the respective disease. Nevertheless, the new taxon-disease relationship can be inferred by combining the predicted balance-disease associations with the evidenced taxon-disease associations under some circumstances, as illustrated on the "Tutorial" page.
The "Species_infer" collum of the table below is all the taxon-disease association inferences based on the current version of GBDAD for shotgun metagenomics and amplicon diseases.